Hematopoietic Cell Transplantation-Comorbidity Index (HCT-CI)


This website was developed to provide an accurate and user-friendly calculation of the HCT-CI scores. The HCT-CI is a comorbidity index that comprises 17 different categories of organ dysfunction. Positive findings are summated into a total score. The HCT-CI provides information with regard to the overall as well as non-relapse mortality risk a patient is likely to experience after hematopoietic cell transplantation. This information can only be used by experienced physicians in the context of other risk factors for mortality such as the degree of cancer severity and the type of transplant.

The HCT-CI was initially designed using clinical data from 1055 consecutive patients treated with allogeneic HCT from 1997 to 2004 at the Seattle Cancer Care Alliance (SCCA)/Fred Hutchinson Cancer Research Center (FHCRC).[1] The index was validated among patients transplanted at the SCCA/FHCRC, [2] as well as other transplant institutions world-wide.[3-5] Multi-institutional validation of the predictive power of the HCT-CI is ongoing. The HCT-CI was shown to be an important decision-making instrument for choosing appropriate conditioning regimens for patients with acute myeloid leukemia or myelodysplastic syndromes [6] and those with lymphoma or chronic lymphocytic leukemia.[7] The HCT-CI together with the degree of severity of blood cancer could be used to stratify outcomes of patients 60 years or older who were treated with a minimally-toxic nonmyeloablative conditioning regimen and allogeneic HCT.[8] Recently, a combined HCT-CI/age index was designed and validated that takes into account the burden of comorbidities as well as increasing age in risk-assessment.[9]

Using The Calculator

Click below on the Calculator link to proceed to the HCT-CI calculator.
We have removed the registration requirement for this web site. There is no longer any need to login to use the calculator or save/restore values.